12/29/2022 0 Comments Are molecules smaller than cells![]() ![]() ![]() SMDC drugs are composed of small molecules, which are easy to control the synthesis process and cost. Nevertheless, SMDC has its own advantages. The use of site-specific coupling technology can achieve a relatively accurate drug-to-antibody ratio (DAR), while SMDC’s small molecule targeting ligands and payloads usually have accurate values. In the preparation of ADC, the ratio of payload to the antibody is usually uncertain. ADC uses biological antibodies as drug targeting, while SMDC uses small molecule targeting. The biggest difference between SMDC and ADC is the targeted ligands. Generally speaking, SMDC and ADC, and even PROTAC have similar compositions, which are composed of targeted ligands, linkers, and drug payload (cytotoxicity, E3 ligase). Overview of Small Molecule-Drug Conjugates (SMDCs)Ĭompared with ADCs, small molecule-drug conjugates (SMDCs) provide a new, less established perspective for targeted delivery. On the contrary, small molecule-drug conjugates (SMDC), which are very similar to ADC drugs, are still advancing in a stumble, and have not yet made breakthrough progress. In particular, Gilead did not hesitate to acquire Immunomedics for US$21 billion in all cash to obtain ADC drugs targeting Trop-2, making ADC a hot topic of the year. Antibody-drug conjugate (ADC) has ushered in a bright moment of development in the past two years and has received a lot of attention. ![]()
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